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The Role of Extracellular Matrix in Cancer Development and Progression

The extracellular matrix (ECM) scaffold, which surrounds and supports the cells in tissues, consists of fibrillar proteins, proteoglycans, glycosaminoglycans, signaling molecules, and enzymes involved in its remodeling. The stages of cancer progression, e.g., local invasion, intravasation, extravasation, distant invasion and immunosuppression, are obligatorily perpetrated through interactions of these tumor cells with the ECM. Cancer-related ECM changes can be exploited for the evaluation of disease progression, anticancer therapy development, and monitoring of therapy response. Thus, in breast cancer, hyaluronan-mediated wound repair mechanisms are hijacked to promote tumor development. Altered mechanical properties of the pancreatic cancer ECM are immunosuppressive and prevent the penetration of cytotoxic chemotherapy agents. The expression of the proteoglycan syndecan-4 is modulated by anticancer drugs, suggesting its potential druggabilty capacity. Another proteoglycan, lumican, is proposed as a cancer prognosis marker, chemoresistance regulator, and cancer therapy target. Due to their remodeling properties, the MMPs are vital mediators and important therapeutic targets. Treatment of breast cancer cells with sulfated hyaluronan has been shown to attenuate tumor cell growth, migration, and invasion. Extracellular vesicles (EVs), comprising exosomes, microvesicles, and apoptotic bodies, are released by all cells into the ECM and body fluids and can be utilized as diagnostic markers in malignant pleural mesothelioma. These exciting developments encourage tumor biology scientists for further creative research.

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Price: 60.99 EUR excl. shipping

Immune Modulation after Coronary Artery Bypass Graft Operation

Immune Modulation after Coronary Artery Bypass Graft Operation ab 48.99 € als Taschenbuch: The Role of ST2 in the Development of Systemic Immunosuppression after Heart Surgery. Aus dem Bereich: Bücher, Wissenschaft, Medizin,

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Price: 48.99 EUR excl. shipping

Immunology

Immunology ab 45.49 € als Taschenbuch: Mantoux test Immune system Vaccine Vaccination Allergy Inoculation ELISA Allergen Herd immunity Dendritic cell Oligoclonal band Organ transplantation Immunosuppression Autoimmunity Polyclonal B cell response. Aus dem Bereich: Bücher, Taschenbücher, Naturwissenschaft,

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Price: 45.49 EUR excl. shipping

Inflammation Mastery 4th Edition

Inflammation Mastery 4th Edition ab 323.99 € als Taschenbuch: The Colorful and Definitive Guide Toward Health and Vitality and away from the Boredom Risks Costs and Inefficacy of Endless Analgesia Immunosuppression and Polypharmacy. Aus dem Bereich: Bücher, Taschenbücher, Naturwissenschaft,

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Price: 323.99 EUR excl. shipping

Inflammation Mastery 4th Edition

Inflammation Mastery 4th Edition ab 202.99 € als epub eBook: The Colorful and Definitive Guide Toward Health and Vitality and away from the Boredom Risks Costs and Inefficacy of Endless Analgesia Immunosuppression and Polypharmacy. Aus dem Bereich: eBooks, Fachthemen & Wissenschaft, Medizin,

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Price: 202.99 EUR excl. shipping

Inflammation Mastery 4th Edition

Inflammation Mastery 4th Edition - The Colorful and Definitive Guide Toward Health and Vitality and away from the Boredom Risks Costs and Inefficacy of Endless Analgesia Immunosuppression and Polypharmacy: ab 202.99 €

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Price: 202.99 EUR excl. shipping